Therapy by Alice 
Heart and Harmony Music Therapy
Posted on April 26, 2020 Leave a Comment
Nikki Belshe is a brilliant music therapist and she is just killing it. I wish I had as much creativity in my pinky as she has in her entire body! She is already doing the work I would like to be doing. Thanks Nikki for sharing this valuable too.
Understanding Covid 19’s Cytokine Storm
Posted on April 22, 2020 Leave a Comment
Although our understanding of how the coronavirus affects the body is still very incomplete (and changing rapidly), we do know the virus’s effects vary tremendously from person to person. Some infected people have no symptoms at all; others have a cough and sore throat; some need medical care and may even die as their inflamed lungs and organs fail. Evidence is mounting that in a number of those fatal cases, it isn’t the virus itself that kills the host, but rather, it is the body’s own out-of-control inflammatory reactions, snowballing into a “cytokine storm” that deals the fatal blow.
So, what are cytokines and how can they kill? Does this help us understand anything about other kinds of inflammation? WHAT ARE CYTOKINES?
When the body’s immune cells detect pathogens or tissue damage, they secrete cytokines (Image 1) to signal, mobilize, and instruct other immune processes and cells. The word cytokine, in fact, comes from the Greek κύτος (kytos) or “cell,” plus κίνησις (kinēsis) or “movement.” Simplified, cytokines are cell movers. Though cytokines are relatively simple protein molecules, their complex functioning and interactions are still being deciphered. We know cytokines can be inflammatory (turning up immune processes); anti-inflammatory (turning off inflammation); or inflammation-resolving
(by signaling “next” in the progression of normally self-resolving inflammatory phases that lead toward healing). In other words, cytokines orchestrate, modulate, and time each phase of normal inflammatory progression. Except in some cases, this orchestration goes very wrong. When a virus like COVID-19 infects the lungs, it hijacks cells there and turns them into virus factories. This damages the cells and releases inflammatory cytokines. These acute-phase cytokines have several important effects:
• They painfully irritate nearby nerve endings, triggering the aches and pains typical of influenza (causing the host to modify its behavior, and rest).
• They summon other immune cells (to attack the invader and damaged tissues). Cytokines are the immune system’s inflammatory messengers and coordinators: when immune cells detect pathogens or tissue damage, they secrete cytokines to signal and regulate inflammatory cells and processes.
Although our understanding of how the coronavirus affects the body is still very incomplete (and changing rapidly), we do know the virus’s effects vary tremendously from person to person. Some infected people have no symptoms at all; others have a cough and sore throat; some need medical care and may even die as their inflamed lungs and organs fail. Evidence is mounting that in a number of those fatal cases, it isn’t the virus itself that kills the host, but rather, it is the body’s own out-of-control inflammatory reactions, snowballing into a “cytokine storm” that deals the fatal blow.
• They make cell and vessel walls leaky (which helps transport the important immune cells and chemicals to where they’re needed most).
So far, so good—all of these inflammatory functions are healthy, normal, and needed. In most cases, the immune
system’s anti-inflammatory and resolution-
triggering mechanisms come to bear, winding down these acute inflammatory reactions. Tissue healing progresses, sensation normalizes, and function returns. THE CYTOKINE STORM
But, for reasons we don’t entirely understand, in about 15 percent of people battling any serious infection,1 the immune
cycle seems to get stuck in a raging release of more and more cytokines, leading to more cell death, and even more cytokines. Perhaps related to underlying genetic defects,2 this phenomenon (first described in
1993) has been long studied in related forms such as systemic inflammatory response syndrome, cytokine release syndrome,
macrophage activation syndrome, hemophagocytic lymphohistiocytosis, or cytokine storm syndrome (CSS).3 In the
1918 Spanish flu epidemic, differences in cytokine storm reactions between old and young, and between that virus and COVID-19, are thought to explain why that epidemic killed so many young people. CSS doesn’t just occur in influenza, but in other respiratory diseases caused by coronaviruses, as well, such as SARS and MERS. They are also associated with noninfectious diseases such as multiple sclerosis and pancreatitis. But whenever cytokine orchestration has turned into
a cytokine storm, their normally helpful
functions contribute to an escalating spiral of worsening symptoms:
• The pain, sensitivity, and fatigue from influenza’s cytokines can make the host inhibit breathing and movement, so much that the concentrated and by-
now toxic inflammatory soup collects in the lungs’ alveoli (Image 2).
• The cytokine-summoned first-responder cells are aggressive and indiscriminate in their destruction. Flooding into the tissues on the wash of leaked interstitial fluids, they use powerful enzymatic and oxidative processes to demolish both friend and foe alike (Image 3). Other cells, such as fibroblasts, simultaneously try to repair this ongoing damage, but when the cytokine-induced destruction continues, New! ABMP Pocket Pathology at http://www.abmp.com/abmp-pocket-pathology-app. 81
the resulting excess collagen makes tissues denser and more fibrous, further inhibiting normal perfusion and drainage.4
• In musculoskeletal tissues, the plasma leakage of acute inflammation causes its characteristic swelling and redness. In lung tissue, this fluid buildup causes coughing; and if excessive or prolonged, can lead to breathing difficulties and pneumonia. What’s more, capillaries damaged by the inflammatory riot can let the cytokine-rich fluids spill over into the bloodstream, resulting in systemic inflammation and multi-organ failure.5
Microdamage to the lungs’ alveoli from virus replication can, in some cases, trigger a self-escalating “cytokine storm” of hyperinflammatory cytokine overproduction and further tissue damage.
WHERE DOES THIS LEAVE US?
If there’s good news in the cytokine storm story, it might be that these cytokine imbalances appear to be detectable (and to some extent, treatable) in COVID-19 patients via commonly available blood tests and immunosuppressive drugs. When excessive inflammation is found in a coronavirus patient, doctors face a tricky decision about how much to suppress the immune system in the face of an active infection, but as experience dealing with this virus mounts, protocols will emerge to help guide these treatment decisions. As has happened with past epidemics, the flood of attention, awareness, and resources will increase our overall understanding of how inflammation gets out of control in other conditions. And there are many, many of those conditions: virtually all musculoskeletal complaints, the majority of chronic diseases, and a growing list of psychological and behavioral conditions are now understood to have a primary inflammatory component. For now, many bodyworkers, manual therapists, and massage therapists are restlessly watching the COVID-19 story unfold from the sidelines. We’re looking and learning while in this holding pattern, but at some point, we’ll have our work to do: helping people stay healthy now has even more important implications than it used to. Immune competence is emerging as a key factor in overall health, and we have clear contributions to make there. As time passes, we will learn more about how we can support post-coronavirus recovery of both individual survivors, and of our world.
Notes
1 Cytokines are the immune system’s inflammatory messengers and coordinators: when immune cells detect pathogens or tissue damage, they secrete cytokines to signal and regulate inflammatory cells and processes.
2 Microdamage to the lungs’ alveoli from virus replication can, in some cases, trigger a self-escalating “cytokine storm” of hyperinflammatory
cytokine overproduction and further tissue damage.
3 Lung tissue sample from a 1918 influenza victim, showing extensive damage to alveoli from inflammatory cell infiltration.
- R. Cron, as quoted in Apoorva Mandavilli, “The
Coronavirus Patients Betrayed by Their Own
Immune Systems,” New York Times, April 1,
2020, http://www.nytimes.com/2020/04/01/health/
coronavirus-cytokine-storm-immune-system.html. - Grant S. Schulert et al., “Whole-Exome Sequencing
Reveals Mutations in Genes Linked to Hemophagocytic
Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza,” Journal
of Infectious Diseases 213, no. 7 (April 2016):
1180–88, https://doi.org/10.1093/infdis/jiv550. - J. L. Ferrara, S. Abhyankar, and D. G. Gilliland,
“Cytokine Storm of Graft-Versus-Host Disease: A
Critical Effector Role for Interleukin-1,” Transplantation Proceedings 25 (February 1993): 1,216 –17. - J. R. Tisoncik et al., “Into the Eye of the
Cytokine Storm,” Microbiology and Molecular Biology Reviews 76, no. 1 (2012): 16–32,
https://doi.org/10.1128/MMBR.05015-11. - Fields Virology, 6th ed., eds. David M. Knipe and
Peter M. Howley (Philadelphia: Wolters Kluwer/
Lippincott Williams & Wilkins Health, 2013).
Til Luchau is the author of Advanced Myofascial Techniques (Handspring Publishing, 2016), a Certified Advanced Rolfer, and a member of the Advanced-Trainings.com faculty, which offers online learning and in-person seminars throughout the United States and abroad. He invites questions or comments via info@advanced-trainings.com and Advanced-Trainings.com’s Facebook page.
Coronavirus…Again
Posted on April 15, 2020 Leave a Comment
Coronavirus got me like…. 🦠
- Thankful I work from home and not with little kids everyday. 😷
- Yes I’m out and about living life but am taking our immunity, and super reds and super greens like crazy 🙃
- I’m getting to ride my horses more often than if I was working and I haven’t had to worry about paying the bills as much as if I hadn’t had this business and my health.
Y’all I have the ✌🏻 solutions for you 😜. Come join me and make money from your home + I got the best IMMUNITY BOOSTERS ever.
Coronavirus ain’t gonna be touching me ✌🏻 We are all in this together
It’s a miracle
Posted on April 14, 2020 Leave a Comment
2 pills •90 days •
31lbs gone
[[^^in a test study]] Who’s wants to lose 10-30 lbs by May? 🙋🏼♀️
Monthly Cleanse
Posted on April 13, 2020 Leave a Comment
I was so bad with my eating this last week with Easter, stress and just everything going but I did my cleanse…and I still managed to be down from last week.
After all of the yummy food🍴 that took place this past weekend, my body definitely needs to 𝓻𝓮𝓼𝓮𝓽 & 𝓻𝓮𝓫𝓪𝓵𝓪𝓷𝓬𝓮 👌🏻
I was feeling sluggish, groggy and not myself. So I pulled out my gentle two day cleanse to get back on track and feeling like me again💁🏼♀️ NO MORE BLOAT!!!
If you are feeling the same- you may be in need of a RESET👊🏼. I only have a few spots left. Message me to get started!💕
Type DETOX” below if you want info!
Luck!
Posted on April 12, 2020 Leave a Comment
Being successful isn’t luck. It’s a choice! You have to choose every single morning and every single night that you are going to bust your butt until the job is done❗️
I choose success.
I will never look at my menagerie of rescue animals and say “sorry guys I spent too much time sleeping in and watching Netflix, now there’s no money for feed.”
You want to know why? Because saying you can’t do it is an excuse to get yourself out of having to work hard.
Get up.
Get dressed.
Throw some confidence in your face and get moving❗️
Your babies deserve it.
Your husband deserves it.
Your family deserves it.
YOU deserve it
Last day for this special. Ends at 11:59 pm Eastern time. Go to Aliceperryman.net and go to pick two or drop me a message on facebook.
Keeping It Real!!!
Posted on April 11, 2020 Leave a Comment
𝙸𝚏 𝚢𝚘𝚞 𝚔𝚗𝚘𝚠 𝚖𝚎 – 𝙸 𝚔𝚎𝚎𝚙 𝚒𝚝 𝚙𝚛𝚎𝚝𝚝𝚢 𝚛𝚎𝚊𝚕.
🤷🏼♀️ Not one to sugar coat things and I’ll pretty much tell ya like it is soooo 𝒽ℯ𝓇ℯ 𝓌ℯ ℊℴ.
Your life will not CHANGE until you choose to change it. I get message after message from people desperately needing an extra income and then back out because they are afraid, don’t have experience or don’t have the money.
Let me tell you something.
No one joins this business because they HAVE money, they are unafraid, or with zero doubts. We all are human. But ya know what? If you’re not changing it you’re choosing it and I just can’t understand how people choose to be broke. #letmehelpyou
I was afraid but I was even more afraid of not breaking the cycle!
broke👏is👏no👏joke👏
Make a change or stay where you are. It’s as simple as that. If you are willing to work hard and be coachable we can team up and do some BIG things- but the first step in changing your life is 𝕊𝔸𝕐𝕀ℕ𝔾 𝕐𝔼𝕊!
keepitreal #findaway
𝙰 𝚍𝚊𝚢 𝚠𝚒𝚝𝚑𝚘𝚞𝚝 𝒸ℴ𝒻𝒻ℯℯ 𝚒𝚜 𝚕𝚒𝚔𝚎…𝚓𝚞𝚜𝚝 𝚔𝚒𝚍𝚍𝚒𝚗𝚐, 𝙸 𝚑𝚊𝚟𝚎 𝚗𝚘 𝚒𝚍𝚎𝚊. 🤣
Posted on April 10, 2020 Leave a Comment
ɪ ᴡᴀᴋᴇ ᴜᴘ ᴇᴠᴇʀʏ ᴍᴏʀɴɪɴɢ ʟᴏᴏᴋɪɴɢ ғᴏʀᴡᴀʀᴅ ᴛᴏ ᴛʜɪs ғᴏʀ ᴍᴜʟᴛɪᴘʟᴇ ʀᴇᴀsᴏɴs:
☕️I’m not spending $5.75/day to get my coffee fix at a local Starbucks.. filled with fat!
☕️Unlike my other coffee, this one 𝗯𝘂𝗿𝗻𝘀 𝗳𝗮𝘁 and is the reason for my 5 lb weightloss along with healthier eating
☕️It serves as a 𝕞𝕖𝕒𝕝 𝕣𝕖𝕡𝕝𝕒𝕔𝕖𝕞𝕖𝕟𝕥 and keeps me full for hours
☕️It has nootropics which help to post your mood and is seriously life changing for someone who suffers from anxiety and depression!
☕️It’s a French roast, which means you can customize with your own creamer.
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To get yours, drop a 💁🏻♀️ emoji below, or PM me!
Therapy by Alice 